Blar i forfatter "Toft, Helge"

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    • Inflammatory cytokines in alcohol use disorder patients are lower in smokers and users of smokeless tobacco 

      Bolstad, Ingeborg; Lien, Lars; Moe, Jenny Skumsnes; Pandey, Susmita; Toft, Helge; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-19)
      Background - Smoking and alcohol use often co-occur, and the use of nicotine-containing products is particularly common among persons with alcohol use disorder (AUD). Recent evidence shows that chronic alcohol use leads to inflammation through increased gut permeability and dysregulated cytokine levels. While cigarette smoking also has detrimental health effects, nicotine has immune dampening effects ...

    • Levels of Peripheral Circulating IL-6 and IL-10 Decrease Over Time Despite High Depression Burden in PTSD Patients 

      Bramness, Jørgen Gustav; Lien, Lars; Toft, Helge (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-05)
      Background: Patients with combined depression symptoms and post-traumatic stress disorder (PTSD) often exhibit high levels of circulating inflammatory biomarkers as either a cause or consequence of their disease. We aimed to investigate how cytokines and depression symptoms develop with one-year follow-up and compare them with non-PTSD patients.<p> <p>Methods: The study had a longitudinal design ...

    • Longitudinal determinants of insomnia among patients with alcohol use disorder 

      Bolstad, Ingeborg; Toft, Helge; Lien, Lars; Moe, Jenny Skumsnes; Rolland, Benjamin; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)
      Insomnia is common among patients with AUD and can impair quality of life and cognitive functioning, as well as cause psycho-social problems and increased risk of relapse. Nonetheless, determinants of insomnia in patients with AUD have scarcely been studied. We aimed to examine prevalence and development of self-perceived insomnia among inpatients in treatment for AUD, and to examine factors in ...

    • Persistent level of mental distress in PTSD patients is not reflected in cytokine levels 1 year after the treatment 

      Toft, Helge; Bramness, Jørgen Gustav; Tilden, Terje; Bolstad, Ingeborg; Lien, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-27)
      <i>Objective</i>: Cross-sectional data show that post-traumatic stress disorder (PTSD) patients often have increased levels of circulating inflammatory markers. There is, however, still a paucity of longitudinal studies with long follow-up times on levels of cytokines in such patients. The current study assesses patients with and without PTSD diagnosis 1 year after discharge from inpatient ...